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Darrera modificació: 2013-12-04
Bases de dades: Sciència.cat
Watkins, Frances - Pendry, Barbara - Corcoran, Olivia - Sánchez-Medina, Alberto, "Anglo-Saxon pharmacopoeia revisited: a potential treasure in drug discovery", Drug Discovery Today, 16/23-24 (2011), 1069 - 1075.
- Resum
- Three of the four major Anglo-Saxon collections reporting medicinal formulations in England from the 10th century, the Old English Herbarium, Bald's Leechbook and the Lacnunga, could contain leads and insights into new medicinal uses. Previous pharmacological studies of medicinal plants mentioned in Anglo-Saxon medical texts suggested that some were effective and led to the identification and isolation of natural compounds. For example, matricin from yarrow Achillea millefolium L., is a proprionic acid analogue that yields chamazulene carboxylic acid with cyclooxygenase-2 activity similar to that of ibuprofen. As we discuss here, multidisciplinary projects could further explore historical texts to discover additional plant metabolites with potential pharmacological applications.
Contents: Introduction -- Anglo-Saxon medical texts -- Recent translations illuminate Anglo-Saxon medical practice -- Bioactive metabolites from medicinal plants in Anglo-Saxon England -- Achillea millefolium (Asteraceae) -- Marrubium vulgare (Lamiaceae) -- Hypericum perforatum (Hypericaceae) -- Concluding remarks -- Acknowledgements -- References
- Matèries
- Medicina - Farmacologia
Anglès
Fonts
- URL
- http://dx.doi.org/10.1016/j.drudis.2011.07.002
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