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Darrera modificació: 2023-10-02
Bases de dades: Sciència.cat
Hama, Hamadou Oumarou - Boualam, Mahmoud A. - Levasseur, Anthony - Ardagna, Yann - Adalian, Pascal - Chaix, Annie-Claire - Drancourt, Michel, "Old World Medieval Treponema pallidum Complex Treponematosis: A Case Report", The Journal of Infectious Diseases, 228/5 (2023), 503-510.
- Resum
- Background
Introduction of 1 Treponema pallidum complex pathogen in naive European populations following the return of Christopher Columbus' troops from Central America in 1493 is a central dogma in venereology.
Methods
Among skeletal elements from the seventh or eighth century uncovered in Roquevaire, France, individual RS-1003 femur macroscopically suspected of having an infectious disease was investigated by means of paleoautoimmunohistochemistry, direct metagenomics, and paleoserology, along with 1 control femur from an apparently healthy individual (R-1003) and experimental negative controls.
Results
RS-1003 femur showed infectious bone; paleoautoimmunohistochemistry of the lesions led to microscopic detection of a T. pallidum complex pathogen. Phylogenetic analyses comprising 71 T. pallidum complex–specific reads covering 2.37% of the T. pallidum subsp. pallidum reference genome sequence revealed an ancestral T. pallidum complex pathogen in the lesion. Paleoserology detecting T. pallidum–specific antigens confirmed positive serological findings in individual RS-1003. Individual R-1003 and the negative controls remained negative.
Conclusions
This case, predating by 8 centuries previous detections of T. pallidum complex treponematosis in Europe, indicated that European populations were not naive to these pathogens before the 1493 introduction of a Central American T. pallidum complex pathogen overwhelming the T. pallidum ones previously circulating in the Old World. These data break a century-old dogma in medical microbiology.
- Matèries
- Medicina - Pesta i altres malalties
- URL
- https://academic.oup.com/jid/article-abstract/228/5 ...
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